Most Cited Article: HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

HSP90 Inhibitors: Current Development and Potential in Cancer Therapy Author(s): Katerina Sidera and Evangelia PatsavoudiPages 1-20 (20) Abstract: In the last decade, the molecular chaperone HSP90 has emerged as an important target in cancer therapeutics and has subsequently become the focus of several drug discovery and development efforts. The first-in-class HSP90 inhibitor 17-AAG entered into Phase I clinical trial in 1999. Today 13 HSP90 inhibitors representing multiple drug classes, with different modes of action, are undergoing clinical...

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Causal Therapy of Breast Cancer Irrelevant of Age, Tumor Stage and ER-Status: Stimulation of Estrogen Signaling Coupled With Breast Conserving Surgery*

Article Details Causal Therapy of Breast Cancer Irrelevant of Age, Tumor Stage and ER-Status: Stimulation of Estrogen Signaling Coupled With Breast Conserving Surgery* [ Vol. 11 , Issue. 3 ] Author(s): Zsuzsanna SubaPages 254-266 (13) Abstract: Background: Results of long-term studies justify that the rate of breast cancer recurrence and tumor-related mortality remains quite unpredictable, regardless of the use of any current therapeutic measures. Objective: Since the application of standard therapies, such as surgery, radiation,...

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Open Access Plus ::: Recent Patents on Anti-Cancer Drug Discovery

Open Access Plus ::: Recent Patents on Anti-Cancer Drug Discovery Circulatory Estrogen Level Protects Against Breast Cancer in Obese WomenZsuzsanna Suba Abstract: The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing...

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Most cited articles from the jorunal ‘Recent Patents on Anti-Cancer Drug Discovery’

Involvement of Endoplasmic Reticulum Stress in Isoliquiritigenin-Induced SKOV-3 Cell Apoptosis Author(s): Xuan Yuan, Bacui Yu, Yanming Wang, Jiangtao Jiang, Liangliang Liu, Hong Zhao, Wang Qi and Qiusheng Zheng. Abstract: Isoliquiritigenin (ISL), a licorice chalconoid, is a bioactive agent with chemopreventive potential that has been patented for tumor treatment in China. This study investigated the mechanisms of ISL-induced apoptosis in ovarian carcinoma SKOV-3 cells. Cell viability was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium...

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New Issue::: Recent Patents on Anti-Cancer Drug Discovery, 11 Issue 1

Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles, and guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs & targets. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal...

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Video presentation on the journal ‘Recent Patents on Anti-Cancer Drug Discovery ‘

Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles, and guest edited thematic issues on recent patents in the field of anti-cancer drug discovery. Details here: http://bit.ly/1i3VfD1 courtesy by : https://benthamsciencepublishers.wordpress.com/2015/10/06/video-presentation-on-the-journal-recent-patents-on-anti-cancer-drug-discover...

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Last published issue of 2015 of the journal ‘Recent Patents on Anti-Cancer Drug Discovery’ is now available online

Recent Patents on Anti-Cancer Drug Discovery,Volume 10–Number 3 Meet Our Editorial Board Member:, 10(3): 243Patrick Legembre. pH Gradient Reversal: An Emerging Hallmark of Cancers,10(3): 244 – 258Mohit Sharma, Madhusudan Astekar, Sonal Soi, Bhari S. Manjunatha,Devi C. Shetty and Raghu Radhakrishnan. Cabozantinib in Thyroid Cancer , 10(3): 259 – 269 Poupak Fallahi, Silvia M. Ferrari, Flavia Di Bari, Gabriele Materazzi,Salvatore Benvenga, Paolo Miccoli and Alessandro...

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